TY - JOUR
T1 - Inflammaging and Blood Pressure Profiles in Late Life
T2 - The Screening for CKD among Older People across Europe (SCOPE) Study
AU - Tap, Lisanne
AU - Corsonello, Andrea
AU - Di Rosa, Mirko
AU - Fabbietti, Paolo
AU - Formiga, Francesc
AU - Moreno-González, Rafael
AU - Ärnlöv, Johan
AU - Carlsson, Axel C.
AU - Polinder-Bos, Harmke A.
AU - Roller-Wirnsberger, Regina E.
AU - Wirnsberger, Gerhard H.
AU - Kostka, Tomasz
AU - Guligowska, Agnieszka
AU - Artzi-Medvedik, Rada
AU - Yehoshua, Ilan
AU - Weingart, Christian
AU - Sieber, Cornel C.
AU - Gil, Pedro
AU - Lainez Martinez, Sara
AU - Lattanzio, Fabrizia
AU - Mattace-Raso, Francesco U.S.
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP −2.94 mmHg, p = 0.032 and PP −2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension.
AB - The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP −2.94 mmHg, p = 0.032 and PP −2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension.
KW - blood pressure
KW - hypertension
KW - inflammation
KW - neutrophil-to-lymphocyte ratio
KW - older adults
KW - vascular aging
UR - http://www.scopus.com/inward/record.url?scp=85144704889&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/jcm11247311
DO - https://doi.org/10.3390/jcm11247311
M3 - مقالة
C2 - 36555930
SN - 2077-0383
VL - 11
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 24
M1 - 7311
ER -