Induced epigenetic changes memorized across generations in mice

Saifeng Cheng; Yoav Mayshar; Yonatan Stelzer

doi:10.1016/j.cell.2023.01.023

Induced epigenetic changes memorized across generations in mice

Saifeng Cheng, Yoav Mayshar, Yonatan Stelzer

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Cell
Volume	186
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2023.01.023
State	Published - 16 Feb 2023

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2023.01.023

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title = "Induced epigenetic changes memorized across generations in mice",

abstract = "Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.",

author = "Saifeng Cheng and Yoav Mayshar and Yonatan Stelzer",

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year = "2023",

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doi = "10.1016/j.cell.2023.01.023",

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AU - Cheng, Saifeng

AU - Mayshar, Yoav

AU - Stelzer, Yonatan

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PY - 2023/2/16

Y1 - 2023/2/16

N2 - Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

AB - Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

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U2 - 10.1016/j.cell.2023.01.023

DO - 10.1016/j.cell.2023.01.023

M3 - تعليقَ / نقاش

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VL - 186

SP - 683

EP - 685

JO - Cell

JF - Cell

IS - 4

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Induced epigenetic changes memorized across generations in mice

Abstract

All Science Journal Classification (ASJC) codes

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