Abstract
Identification and manipulation of different GABAergic interneuron classes in the behaving animal are important to understand their role in circuit dynamics and behavior. The combination of optogenetics and large-scale neuronal recordings allows specific interneuron populations to be identified and perturbed for circuit analysis in intact animals. A crucial aspect of this approach is coupling electrophysiological recording with spatially and temporally precise light delivery. Focal multisite illumination of neuronal activators and silencers in predetermined temporal configurations or a closed loop manner opens the door to addressing many novel questions. Recent progress demonstrates the utility and power of this novel technique for interneuron research.
Original language | English |
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Pages (from-to) | 88-95 |
Number of pages | 8 |
Journal | Current Opinion in Neurobiology |
Volume | 26 |
DOIs | |
State | Published - Jun 2014 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience