In vivo minimally invasive interstitial multi-functional microendoscopy

Asaf Shahmoon; Shiran Aharon; Oded Kruchik; Martin Hohmann; Hamutal Slovin; Alexandre Douplik; Zeev Zalevsky

doi:https://doi.org/10.1038/srep01805

In vivo minimally invasive interstitial multi-functional microendoscopy

Asaf Shahmoon, Shiran Aharon, Oded Kruchik, Martin Hohmann, Hamutal Slovin, Alexandre Douplik, Zeev Zalevsky

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200â€...μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1â€...μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.

Original language	English
Article number	1805
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep01805
State	Published - 2013

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title = "In vivo minimally invasive interstitial multi-functional microendoscopy",

abstract = "Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200{\^a}€...μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1{\^a}€...μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.",

author = "Asaf Shahmoon and Shiran Aharon and Oded Kruchik and Martin Hohmann and Hamutal Slovin and Alexandre Douplik and Zeev Zalevsky",

note = "Funding Information: The authors would like to acknowledge the financial support given to this research from NIH grant R21 5R21EB009138-02 entitled {\textquoteleft}{\textquoteleft}Novel nano-pipette for imaging of deep cortical layers and deep brain structures{\textquoteright}{\textquoteright}. Zeev Zalevsky also gratefully acknowledges the Leon and Maria Taubenblatt Prize for Excellence in Medical Research for supporting his research activity.",

year = "2013",

doi = "https://doi.org/10.1038/srep01805",

language = "الإنجليزيّة",

volume = "3",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - In vivo minimally invasive interstitial multi-functional microendoscopy

AU - Shahmoon, Asaf

AU - Aharon, Shiran

AU - Kruchik, Oded

AU - Hohmann, Martin

AU - Slovin, Hamutal

AU - Douplik, Alexandre

AU - Zalevsky, Zeev

N1 - Funding Information: The authors would like to acknowledge the financial support given to this research from NIH grant R21 5R21EB009138-02 entitled ‘‘Novel nano-pipette for imaging of deep cortical layers and deep brain structures’’. Zeev Zalevsky also gratefully acknowledges the Leon and Maria Taubenblatt Prize for Excellence in Medical Research for supporting his research activity.

PY - 2013

Y1 - 2013

N2 - Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200â€...μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1â€...μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.

AB - Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200â€...μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1â€...μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.

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DO - https://doi.org/10.1038/srep01805

M3 - مقالة

C2 - 23712369

SN - 2045-2322

VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 1805

ER -

In vivo minimally invasive interstitial multi-functional microendoscopy

Abstract

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