In vitro susceptibility of neisseria gonorrhoeae strains to mupirocin, an antibiotic reformulated for parenteral administration in nanoliposomes

Ahuva Cern; Kristie L. Connolly; Ann E. Jerse; Yechezkel Barenholz

doi:https://doi.org/10.1128/AAC.02377-17

In vitro susceptibility of neisseria gonorrhoeae strains to mupirocin, an antibiotic reformulated for parenteral administration in nanoliposomes

Ahuva Cern, Kristie L. Connolly, Ann E. Jerse, Yechezkel Barenholz

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.

Original language	English
Article number	e02377-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02377-17
State	Published - Apr 2018

Keywords

Antibiotic resistance
Antimicrobial activity
Antimicrobial resistance
Cross-resistance
Liposomes
Nano-mupirocin

All Science Journal Classification (ASJC) codes

Pharmacology (medical)
Infectious Diseases
Pharmacology

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title = "In vitro susceptibility of neisseria gonorrhoeae strains to mupirocin, an antibiotic reformulated for parenteral administration in nanoliposomes",

abstract = "Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.",

keywords = "Antibiotic resistance, Antimicrobial activity, Antimicrobial resistance, Cross-resistance, Liposomes, Nano-mupirocin",

author = "Ahuva Cern and Connolly, {Kristie L.} and Jerse, {Ann E.} and Yechezkel Barenholz",

year = "2018",

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AU - Cern, Ahuva

AU - Connolly, Kristie L.

AU - Jerse, Ann E.

AU - Barenholz, Yechezkel

PY - 2018/4

Y1 - 2018/4

N2 - Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.

AB - Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.

KW - Antibiotic resistance

KW - Antimicrobial activity

KW - Antimicrobial resistance

KW - Cross-resistance

KW - Liposomes

KW - Nano-mupirocin

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M3 - مقالة

C2 - 29339382

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

M1 - e02377-17

ER -

In vitro susceptibility of neisseria gonorrhoeae strains to mupirocin, an antibiotic reformulated for parenteral administration in nanoliposomes

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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