Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66. kDa) of 160. nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.
- Hydrophilic macromolecules
- Transdermal perfusion
All Science Journal Classification (ASJC) codes
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry