Immunometabolic crosstalk during bacterial infection

Gili Rosenberg; Sebastian Riquelme; Alice Prince; Roi Avraham

doi:https://doi.org/10.1038/s41564-022-01080-5

Immunometabolic crosstalk during bacterial infection

Gili Rosenberg, Sebastian Riquelme, Alice Prince, Roi Avraham

Department of Immunology and Regenerative Biology

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Following detection of bacteria, macrophages switch their metabolism from oxidative respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This immunometabolic shift enables pro-inflammatory and antimicrobial responses and is facilitated by the accumulation of fatty acids, tricarboxylic acid-derived metabolites and catabolism of amino acids. Recent studies have shown that these immunometabolites are co-opted by pathogens as environmental cues for expression of virulence genes. We review mechanisms by which host immunometabolites regulate bacterial pathogenicity and discuss opportunities for the development of therapeutics targeting metabolic host-pathogen crosstalk.

Original language	English
Pages (from-to)	497-507
Number of pages	11
Journal	Nature Microbiology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1038/s41564-022-01080-5
State	Published - Apr 2022

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ra_NatMicrobiol_ImmunometabolicCrosstalk_AM2022.pdfAccepted author manuscript, 2.62 MBLicense: Other

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Immunometabolic crosstalk during bacterial infection

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