TY - JOUR
T1 - Immunological Features of Non-neuronal Brain Cells
T2 - Implications for Alzheimer's Disease Immunotherapy
AU - Schwartz, Michal
N1 - We thank Dr Shelley Schwarzbaum for editing the manuscript. Research in the Schwartz laboratory is supported by a European Research Council Advanced Grant (741744), Israel Science Foundation (ISF) research grant no. 991/16, and ISF-Legacy Heritage Bio-medical Science Partnership research grant no. 1354/15. We thank the Adelis and Thompson foundations for their generous support of our AD research.
PY - 2020/9
Y1 - 2020/9
N2 - An interaction network exists among cells within the brain, maintaining brain homeostasis and ensuring its functional plasticity. In addition to neurons, participating cells include astrocytes, oligodendrocytes, and microglia. Peripheral immune cells, such as monocytes and lymphocytes, have also been found to play an important role in supporting the brain in health and assisting in its repair. Here, we describe the multiple immune-specific modes of cellular dialogue among cells within the mammalian brain and their crosstalk with the periphery in both health and disease. We further suggest that interventions directed at boosting the peripheral immune response can restore the balance between the brain and the immune system and can rewire their communication to modify chronic neurodegenerative diseases.
AB - An interaction network exists among cells within the brain, maintaining brain homeostasis and ensuring its functional plasticity. In addition to neurons, participating cells include astrocytes, oligodendrocytes, and microglia. Peripheral immune cells, such as monocytes and lymphocytes, have also been found to play an important role in supporting the brain in health and assisting in its repair. Here, we describe the multiple immune-specific modes of cellular dialogue among cells within the mammalian brain and their crosstalk with the periphery in both health and disease. We further suggest that interventions directed at boosting the peripheral immune response can restore the balance between the brain and the immune system and can rewire their communication to modify chronic neurodegenerative diseases.
UR - http://www.scopus.com/inward/record.url?scp=85089369975&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.it.2020.07.005
DO - https://doi.org/10.1016/j.it.2020.07.005
M3 - مقالة مرجعية
SN - 1471-4906
VL - 41
SP - 794
EP - 804
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -