TY - JOUR
T1 - Immune-Microbiota Interplay and Colonization Resistance in Infection
AU - Leshem, Avner
AU - Liwinski, Timur
AU - Elinav, Eran
N1 - We thank the members of the Elinav lab for discussions and apologize for authors whose work was not cited because of space constraints. E.E. is the incumbent of the Sir Marc and Lady Tania Feldmann Professorial Chair, a senior fellow at the Canadian Institute of Advanced Research, and an international scholar at the Bill & Melinda Gates Foundation and the Howard Hughes Medical Institute. T.L. is funded as postdoctoral fellow by the German Research Foundation (DFG, 420943353). Author contributions - All authors researched data for the article; made substantial contributions to discussion of content; and wrote, reviewed, and edited the manuscript before submission.
PY - 2020/5/21
Y1 - 2020/5/21
N2 - Commensal microbial communities inhabit biological niches in the mammalian host, where they impact the host's physiology through induction of "colonization resistance'' against infections by a multitude of molecular mechanisms. These colonization-regulating activities involve microbe-microbe and microbe-host interactions, which induce, through utilization of complex bacterial networks, competition over nutrients, inhibition by antimicrobial peptides, stimulation of the host immune system, and promotion of mucus and intestinal epithelial barrier integrity. Distinct virulent pathogens overcome this colonization resistance and host immunity as part of a hostile takeover of the host niche, leading to clinically overt infection. The following review provides a mechanistic overview of the role of commensal microbes in modulating colonization resistance and pathogenic infections and means by which infectious agents may overcome such inhibition. Last, we outline evidence, unknowns, and challenges in developing strategies to harness this knowledge to treat infections by microbiota transfer, phage therapy, or supplementation by rationally defined bacterial consortia.
AB - Commensal microbial communities inhabit biological niches in the mammalian host, where they impact the host's physiology through induction of "colonization resistance'' against infections by a multitude of molecular mechanisms. These colonization-regulating activities involve microbe-microbe and microbe-host interactions, which induce, through utilization of complex bacterial networks, competition over nutrients, inhibition by antimicrobial peptides, stimulation of the host immune system, and promotion of mucus and intestinal epithelial barrier integrity. Distinct virulent pathogens overcome this colonization resistance and host immunity as part of a hostile takeover of the host niche, leading to clinically overt infection. The following review provides a mechanistic overview of the role of commensal microbes in modulating colonization resistance and pathogenic infections and means by which infectious agents may overcome such inhibition. Last, we outline evidence, unknowns, and challenges in developing strategies to harness this knowledge to treat infections by microbiota transfer, phage therapy, or supplementation by rationally defined bacterial consortia.
UR - http://www.scopus.com/inward/record.url?scp=85083005970&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2020.03.001
DO - 10.1016/j.molcel.2020.03.001
M3 - مقالة مرجعية
SN - 1097-2765
VL - 78
SP - 597
EP - 613
JO - Molecular Cell
JF - Molecular Cell
IS - 4
ER -