TY - JOUR
T1 - Immune cell type 'fingerprints' at the basis of outcome diversity of human infection
AU - Hen-Avivi, Shelly
AU - Avraham, Roi
N1 - R.A. is supported by a research grant from the Estate of David Turner and from the Merle S. Cahn Foundation and the Estate of Sylvia Holder. This study was supported by the Israel Science Foundation (grant No. 1890/17).
PY - 2018/4
Y1 - 2018/4
N2 - Despite the availability of antibiotics and immunization, infectious diseases remain a major cause of malignancy and death worldwide. Yet, it is well documented that for most infectious agents, clinical disease develops in only a small minority of infected individuals. There is, in fact, great heterogeneity in infection outcome, from complete clearance of the pathogen to severe illness. Understanding this variation remains elusive, despite its great potential to equip us with new tools for the treatment of infectious diseases. Here, we propose a novel perspective for studying this diversity in human infection outcome, one that utilizes single-cell analysis technologies. Recent advances in single-cell RNA-seq technologies allow the detection of rare subpopulations that play important roles in host-pathogen interactions. We propose that applying single-cell RNA-seq to the study of infection can provide a 'fingerprint' of the immune cell types that are associated with the ability of the host to clear a pathogen and, thereby, broaden our current understanding of variation in susceptibility to infection within the population.
AB - Despite the availability of antibiotics and immunization, infectious diseases remain a major cause of malignancy and death worldwide. Yet, it is well documented that for most infectious agents, clinical disease develops in only a small minority of infected individuals. There is, in fact, great heterogeneity in infection outcome, from complete clearance of the pathogen to severe illness. Understanding this variation remains elusive, despite its great potential to equip us with new tools for the treatment of infectious diseases. Here, we propose a novel perspective for studying this diversity in human infection outcome, one that utilizes single-cell analysis technologies. Recent advances in single-cell RNA-seq technologies allow the detection of rare subpopulations that play important roles in host-pathogen interactions. We propose that applying single-cell RNA-seq to the study of infection can provide a 'fingerprint' of the immune cell types that are associated with the ability of the host to clear a pathogen and, thereby, broaden our current understanding of variation in susceptibility to infection within the population.
UR - http://www.scopus.com/inward/record.url?scp=85031711443&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.mib.2017.09.012
DO - https://doi.org/10.1016/j.mib.2017.09.012
M3 - مقالة مرجعية
SN - 1369-5274
VL - 42
SP - 31
EP - 39
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -