Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Hadar Cheriker; Tal Stern Bauer; Yuval Oren; Shlomo Nir; Zvi Hayouka

doi:10.1039/d0cc04759g

Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Hadar Cheriker, Tal Stern Bauer, Yuval Oren, Shlomo Nir, Zvi Hayouka

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

Original language	English
Pages (from-to)	11022-11025
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	75
DOIs	https://doi.org/10.1039/d0cc04759g
State	Published - 25 Sep 2020

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/d0cc04759g

Cite this

@article{4b8c4c6185e5476f83e67ea5b5148479,

title = "Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity",

abstract = "In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.",

author = "Hadar Cheriker and \{Stern Bauer\}, Tal and Yuval Oren and Shlomo Nir and Zvi Hayouka",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",

year = "2020",

month = sep,

day = "25",

doi = "10.1039/d0cc04759g",

language = "الإنجليزيّة",

volume = "56",

pages = "11022--11025",

number = "75",

}

TY - JOUR

T1 - Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

AU - Cheriker, Hadar

AU - Stern Bauer, Tal

AU - Oren, Yuval

AU - Nir, Shlomo

AU - Hayouka, Zvi

N1 - Publisher Copyright: © The Royal Society of Chemistry 2020.

PY - 2020/9/25

Y1 - 2020/9/25

N2 - In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

AB - In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

UR - http://www.scopus.com/inward/record.url?scp=85091471461&partnerID=8YFLogxK

U2 - 10.1039/d0cc04759g

DO - 10.1039/d0cc04759g

M3 - مقالة

C2 - 32959824

SN - 1359-7345

VL - 56

SP - 11022

EP - 11025

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this