Identification of legionella effectors using bioinformatic approaches

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Legionella pneumophila the causative agent of Legionnaires' disease, actively manipulates host cell processes to establish a replication niche inside host cells. The establishment of its replication niche requires a functional Icm/Dot type IV secretion system which translocates about 300 effector proteins into host cells during infection. Many of these effectors were first identified as effector candidates by several bioinformatic approaches, and these predicted effectors were later examined experimentally for translocation and a large number of which were validated as effector proteins. Here, I summarized the bioinformatic approaches that were used to identify these effectors.

Original languageEnglish
Title of host publicationLegionella
Subtitle of host publicationMethods and Protocols
Number of pages8
StatePublished - 2013

Publication series

NameMethods in Molecular Biology

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics


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