Identification and screening of carbapenemase-producing Enterobacteriaceae

P. Nordmann, M. Gniadkowski, C. G. Giske, L. Poirel, N. Woodford, V. Miriagou, M. Akova, T. Naas, H. Seifert, D. Livermore, P. Bogaerts, Y. Glupczynski, R. Canton, M. Rossolini G., A. Adler, Y. Carmeli, S. Navon-Venezia, O. Samuelsen, G. Cornaglia

Research output: Contribution to journalReview articlepeer-review


Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.

Original languageEnglish
Pages (from-to)432-438
Number of pages7
JournalClinical Microbiology and Infection
Issue number5
StatePublished - 1 May 2012


  • Antibiotic
  • Carbapenem
  • Gram-negatives
  • Resistance
  • β-lactams

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Identification and screening of carbapenemase-producing Enterobacteriaceae'. Together they form a unique fingerprint.

Cite this