ICSI increases ongoing pregnancy rates in patients with poor response cycle: Multivariate analysis of 2819 cycles

Ettie Maman, Liat Lerner Geva, Gil Yerushalmi, Micha Baum, Jehoshua Dor, Ariel Hourvitz

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to evaluate the prognosis of patients with a first treatment cycle that was defined as a poor ovarian response cycle according to the new ESHRE consensus criteria. The first documented cycle of poor response for a patient and all the cycles that followed were retrospectively analysed. Factors that were associated with ongoing pregnancy rates were assessed using multivariate analysis. In total, this study evaluated 1014 patients that underwent 2819 consecutive IVF cycles. As expected, patients with poor response cycles were older and had less oocytes retrieved and less embryos transferred. Multivariate analysis for ongoing pregnancy rates adjusted for patient and the cycle characteristics revealed that the intracytoplasmic sperm injection (ICSI) procedure was associated with a significant increase of 40% in ongoing pregnancy rate (adjusted success ratio 1.40, 95% CI 1.00-1.96). Age over 41 years and additional cycles with poor response, were associated with significantly less ongoing pregnancy rate. However, the cumulative pregnancy rates were 29.5% and 36.4% following five and seven cycles, respectively. In conclusion, performing ICSI may improve the ongoing pregnancy rates in poor responders. Further studies are needed to establish the number of cycles recommended in these patients.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalReproductive BioMedicine Online
Volume25
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • ICSI
  • IVF
  • ongoing pregnancy rates
  • ovary
  • poor response

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology

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