Hypothalamic control of sleep in aging

Asya Rolls

doi:10.1007/s12017-012-8175-0

Hypothalamic control of sleep in aging

Research output: Contribution to journal › Review article › peer-review

Abstract

The timing of sleep and its duration are affected by circadian and homeostatic factors. Physiological and behavioral attributes such as the duration of previous wake period, food availability, temperature, and stress all affect sleep and its quality. As many of these physiological inputs are integrated in the hypothalamus, it is not surprising that this brain structure plays a crucial role in the regulation of sleep. I will discuss this role also in the context of aging, which is associated with changes in both hypothalamic function and the composition of sleep.

Original language	English
Pages (from-to)	139-153
Number of pages	15
Journal	NeuroMolecular Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/s12017-012-8175-0
State	Published - Sep 2012
Externally published	Yes

Keywords

Aging
Hypocretin
Hypothalamus
Sleep

All Science Journal Classification (ASJC) codes

Molecular Medicine
Neurology
Cellular and Molecular Neuroscience

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10.1007/s12017-012-8175-0

Cite this

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title = "Hypothalamic control of sleep in aging",

abstract = "The timing of sleep and its duration are affected by circadian and homeostatic factors. Physiological and behavioral attributes such as the duration of previous wake period, food availability, temperature, and stress all affect sleep and its quality. As many of these physiological inputs are integrated in the hypothalamus, it is not surprising that this brain structure plays a crucial role in the regulation of sleep. I will discuss this role also in the context of aging, which is associated with changes in both hypothalamic function and the composition of sleep.",

keywords = "Aging, Hypocretin, Hypothalamus, Sleep",

author = "Asya Rolls",

note = "Funding Information: Acknowledgments I would like to thank Prof. Luis de Lecea and Megha Makam for their comments and EMBO and the NARSAD for funding.",

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PY - 2012/9

Y1 - 2012/9

N2 - The timing of sleep and its duration are affected by circadian and homeostatic factors. Physiological and behavioral attributes such as the duration of previous wake period, food availability, temperature, and stress all affect sleep and its quality. As many of these physiological inputs are integrated in the hypothalamus, it is not surprising that this brain structure plays a crucial role in the regulation of sleep. I will discuss this role also in the context of aging, which is associated with changes in both hypothalamic function and the composition of sleep.

AB - The timing of sleep and its duration are affected by circadian and homeostatic factors. Physiological and behavioral attributes such as the duration of previous wake period, food availability, temperature, and stress all affect sleep and its quality. As many of these physiological inputs are integrated in the hypothalamus, it is not surprising that this brain structure plays a crucial role in the regulation of sleep. I will discuss this role also in the context of aging, which is associated with changes in both hypothalamic function and the composition of sleep.

KW - Aging

KW - Hypocretin

KW - Hypothalamus

KW - Sleep

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JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

IS - 3

ER -

Hypothalamic control of sleep in aging

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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