HyperBIRD: A Sensitivity-Enhanced Approach to Collecting Homonuclear-Decoupled Proton NMR Spectra

Kevin J. Donovan, Lucio Frydman

Research output: Contribution to journalArticlepeer-review


Samples prepared following dissolution dynamic nuclear polarization (DNP) enable the detection of NMR spectra from low- nuclei with outstanding sensitivity, yet have limited use for the enhancement of abundant species like (1)Hnuclei. Small- and intermediate-sized molecules, however, show strong heteronuclear cross-relaxation effects: spontaneous processes with an inherent isotopic selectivity, whereby only the C-13-bonded protons receive a polarization enhancement. These effects are here combined with a recently developed method that delivers homonuclear-decoupled (1)Hspectra in natural abundance samples based on heteronuclear couplings to these same, C-13-bonded nuclei. This results in the HyperBIRD methodology; a single-shot combination of these two effects that can simultaneously simplify and resolve complex, congested (HNMR)-H-1 spectra with many overlapping spin multiplets, while achieving 50-100 times sensitivity enhancements over conventional thermal counterparts.
Original languageEnglish
Pages (from-to)594-598
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number2
StatePublished - 7 Jan 2015


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