Abstract
Abstract: There is currently a high demand for synthetic biodegradable scaffolds with enhanced osteogenic and angiogenic performance for the regeneration of large-size bone defects. Here, hybrid scaffolds were prepared by integrating either alginate or alginate–bioglass composite hydrogels with a 3D-printed poly(lactic acid) (PLA) porous structure. The as-deposited PLA scaffolds were surface treated with polyacrylic acid (PAA), which significantly enhanced the PLA scaffold’s wettability. The surface-modified PLA scaffolds integrated well with hydrogels and provided shape and mechanical rigidity to the hydrogel. In phosphate-buffered saline, the lowest weight loss during 21-days immersion was measured for the PLA scaffold, while alginate–bioglass scaffolds lost ~ 1.9% weight during the first 7 days of immersion. In vitro cytocompatibility tests indicated good cell viability and cell proliferation on the scaffolds. The bioglass-containing hybrid scaffold promoted osteogenic differentiation and calcium mineralization. The excellent biocompatibility, good mechanical stability of the hydrogel, and shape retention of the novel hybrid scaffolds with cell-laden alginate could make them attractive for large bone regeneration. Graphic abstract: [Figure not available: see fulltext.]
Original language | English |
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Pages (from-to) | 3833-3842 |
Number of pages | 10 |
Journal | Journal of Materials Research |
Volume | 36 |
Issue number | 19 |
DOIs | |
State | Published - 14 Oct 2021 |
Keywords
- Additive manufacturing
- Alginate–bioglass hydrogel
- Biomedical
- Bone
- In vitro cell culture
- Poly(lactic acid) (PLA)
All Science Journal Classification (ASJC) codes
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
- General Materials Science