Human renal cancer stem cells

Benedetta Bussolati; Benjamin Dekel; Bruno Azzarone; Giovanni Camussi

doi:10.1016/j.canlet.2012.05.007

Human renal cancer stem cells

Benedetta Bussolati, Benjamin Dekel, Bruno Azzarone, Giovanni Camussi

Pediatrics

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	Cancer Letters
Volume	338
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2012.05.007
State	Published - 10 Sep 2013

Keywords

Angiogenesis
Differentiation therapy
Renal cell carcinoma
Tumor stem cells
Wilms' tumor

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.05.007

Cite this

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title = "Human renal cancer stem cells",

abstract = "Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.",

keywords = "Angiogenesis, Differentiation therapy, Renal cell carcinoma, Tumor stem cells, Wilms' tumor",

author = "Benedetta Bussolati and Benjamin Dekel and Bruno Azzarone and Giovanni Camussi",

note = "Funding Information: This work was supported by Italian Ministry of University and Research PRIN08 and ex60\%. Studies in the Dekel Lab on WT were supported by the Israel Cancer Research Fund (ICRF), Israel Cancer Association (ICA), Ministry of Health Project Grant and the Sheba-MD Anderson Global Academic Program (GAP).",

year = "2013",

month = sep,

day = "10",

doi = "10.1016/j.canlet.2012.05.007",

language = "الإنجليزيّة",

volume = "338",

pages = "141--146",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Human renal cancer stem cells

AU - Bussolati, Benedetta

AU - Dekel, Benjamin

AU - Azzarone, Bruno

AU - Camussi, Giovanni

N1 - Funding Information: This work was supported by Italian Ministry of University and Research PRIN08 and ex60%. Studies in the Dekel Lab on WT were supported by the Israel Cancer Research Fund (ICRF), Israel Cancer Association (ICA), Ministry of Health Project Grant and the Sheba-MD Anderson Global Academic Program (GAP).

PY - 2013/9/10

Y1 - 2013/9/10

N2 - Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.

AB - Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.

KW - Angiogenesis

KW - Differentiation therapy

KW - Renal cell carcinoma

KW - Tumor stem cells

KW - Wilms' tumor

UR - http://www.scopus.com/inward/record.url?scp=84882889737&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2012.05.007

DO - 10.1016/j.canlet.2012.05.007

M3 - مقالة مرجعية

C2 - 22587951

SN - 0304-3835

VL - 338

SP - 141

EP - 146

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Human renal cancer stem cells

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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