TY - JOUR
T1 - Human Olfaction without Apparent Olfactory Bulbs
AU - Weiss, Tali
AU - Soroka, Timna
AU - Gorodisky, Lior
AU - Snitz, Kobi
AU - Weissgross, Reut
AU - Furman-Haran, Edna
AU - Dhollander, Thijs
AU - Sobel, Noam
N1 - This work was funded by a European Research Council AdG. grant #670798 (SocioSmell) awarded to N.S. Data were provided (in part) by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. We thank Liav Tagania for initial demarcation of HCP OBs and Dr. Rita Schmidt for help in optimizing imaging parameters. Author contributions - NAB1 Identification, T.W. and S.S.; Experimental Design, T.W., T.S., L.G., S.S., and N.S.; Experiments: T.W., T.S., L.G., S.S., and R.W.; Optimization of Scanning Parameters, E.F.-H.; Structural and Functional Data Analysis: T.W., T.S., L.G., S.S., K.S., and N.S.; Diffusion Weighted Image Analysis, T.D., Manuscript Writing, T.W., T.S., L.G., T.D., and N.S.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women's brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in ∼0.6% of women and ∼4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system.
AB - The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women's brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in ∼0.6% of women and ∼4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system.
UR - http://www.scopus.com/inward/record.url?scp=85077384073&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neuron.2019.10.006
DO - https://doi.org/10.1016/j.neuron.2019.10.006
M3 - مقالة
SN - 0896-6273
VL - 105
SP - 35-45.e5
JO - Neuron
JF - Neuron
IS - 1
ER -