TY - JOUR
T1 - Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface
AU - Weisblum, Yiska
AU - Panet, Amos
AU - Zakay-Rones, Zichria
AU - Vitenshtein, Alon
AU - Haimov-Kochman, Ronit
AU - Goldman-Wohl, Debra
AU - Oiknine-Djian, Esther
AU - Yamin, Rachel
AU - Meir, Karen
AU - Amsalem, Hagai
AU - Imbar, Tal
AU - Mandelboim, Ofer
AU - Yagel, Simcha
AU - Wolf, Dana G.
N1 - Publisher Copyright: © 2015 Elsevier Inc.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - The initial interplay between human cytomegalovirus (HCMV) and innate tissue response in the human maternal-fetal interface, though crucial for determining the outcome of congenital HCMV infection, has remained unknown. We studied the innate response to HCMV within the milieu of the human decidua, the maternal aspect of the maternal-fetal interface, maintained ex vivo as an integral tissue. HCMV infection triggered a rapid and robust decidual-tissue innate immune response predominated by interferon (IFN)γ and IP-10 induction, dysregulating the decidual cytokine/chemokine environment in a distinctive fashion. The decidual-tissue response was already elicited during viral-tissue contact, and was not affected by neutralizing HCMV antibodies. Of note, IFNγ induction, reflecting immune-cell activation, was distinctive to the maternal decidua, and was not observed in concomitantly-infected placental (fetal) villi. Our studies in a clinically-relevant surrogate human model, provide a novel insight into the first-line decidual tissue response which could affect the outcome of congenital infection.
AB - The initial interplay between human cytomegalovirus (HCMV) and innate tissue response in the human maternal-fetal interface, though crucial for determining the outcome of congenital HCMV infection, has remained unknown. We studied the innate response to HCMV within the milieu of the human decidua, the maternal aspect of the maternal-fetal interface, maintained ex vivo as an integral tissue. HCMV infection triggered a rapid and robust decidual-tissue innate immune response predominated by interferon (IFN)γ and IP-10 induction, dysregulating the decidual cytokine/chemokine environment in a distinctive fashion. The decidual-tissue response was already elicited during viral-tissue contact, and was not affected by neutralizing HCMV antibodies. Of note, IFNγ induction, reflecting immune-cell activation, was distinctive to the maternal decidua, and was not observed in concomitantly-infected placental (fetal) villi. Our studies in a clinically-relevant surrogate human model, provide a novel insight into the first-line decidual tissue response which could affect the outcome of congenital infection.
KW - Congenital viral infection
KW - Decidua
KW - Human cytomegalovirus
KW - Innate immune response
KW - Maternal-fetal interface
KW - Placental infection
UR - http://www.scopus.com/inward/record.url?scp=84940027690&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.virol.2015.06.023
DO - https://doi.org/10.1016/j.virol.2015.06.023
M3 - مقالة
C2 - 26318261
SN - 0042-6822
VL - 485
SP - 289
EP - 296
JO - Virology
JF - Virology
ER -