How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates

Afu Fu; Ido Livneh; Aaron Ciechanover; Victoria Cohen-Kaplan

doi:10.1080/23723556.2021.1989939

How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates

Afu Fu, Ido Livneh, Aaron Ciechanover, Victoria Cohen-Kaplan

Medicine

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are their mechanism of assembly and function. A recent study describing these condensates as hubs for protein degradation by the ubiquitin system may shed a new light on this recent development in cell biology.

Original language	English
Article number	1989939
Pages (from-to)	1989939
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2021.1989939
State	Published - 21 Oct 2021

Keywords

LLPS condensates
p62
proteasome
protein degradation
ubiquitin

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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10.1080/23723556.2021.1989939

Cite this

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abstract = "Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are their mechanism of assembly and function. A recent study describing these condensates as hubs for protein degradation by the ubiquitin system may shed a new light on this recent development in cell biology.",

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How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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