TY - JOUR
T1 - Host genetics and microbiome associations through the lens of genome wide association studies
AU - Weissbrod, Omer
AU - Rothschild, Daphna
AU - Barkan, Elad
AU - Segal, Eran
N1 - Publisher Copyright: © 2018 Elsevier Ltd
PY - 2018/8
Y1 - 2018/8
N2 - Recent studies indicate that the gut microbiome is partially heritable, motivating the need to investigatem microbiome-host genome associations via microbial genome-wide association studies (mGWAS). Existing mGWAS demonstrate that microbiome host genotype associations are typically weak and are spread across multiple variants, similar to associations often observed in genome-wide association studies (GWAS) of complex traits. Here we reconsider mGWAS by viewing them through the lens of GWAS, and demonstrate that there are striking similarities between the challenges and pitfalls faced by the two study designs. We further advocate the mGWAS community to adopt three key lessons learned over the history of GWAS: firstly, adopting uniform data and reporting formats to facilitate replication and meta-analysis efforts; secondly, enforcing stringent statistical criteria to reduce the number of false positive findings; and thirdly, considering the microbiome and the host genome as distinct entities, rather than studying different taxa and single nucleotide polymorphism (SNPs) separately. Finally, we anticipate that mGWAS sample sizes will have to increase by orders of magnitude to reproducibly associate the host genome with the gut microbiome.
AB - Recent studies indicate that the gut microbiome is partially heritable, motivating the need to investigatem microbiome-host genome associations via microbial genome-wide association studies (mGWAS). Existing mGWAS demonstrate that microbiome host genotype associations are typically weak and are spread across multiple variants, similar to associations often observed in genome-wide association studies (GWAS) of complex traits. Here we reconsider mGWAS by viewing them through the lens of GWAS, and demonstrate that there are striking similarities between the challenges and pitfalls faced by the two study designs. We further advocate the mGWAS community to adopt three key lessons learned over the history of GWAS: firstly, adopting uniform data and reporting formats to facilitate replication and meta-analysis efforts; secondly, enforcing stringent statistical criteria to reduce the number of false positive findings; and thirdly, considering the microbiome and the host genome as distinct entities, rather than studying different taxa and single nucleotide polymorphism (SNPs) separately. Finally, we anticipate that mGWAS sample sizes will have to increase by orders of magnitude to reproducibly associate the host genome with the gut microbiome.
UR - http://www.scopus.com/inward/record.url?scp=85048789566&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2018.05.003
DO - 10.1016/j.mib.2018.05.003
M3 - مقالة مرجعية
SN - 1369-5274
VL - 44
SP - 9
EP - 19
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -