High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks

Moataz Assem, Michael G. Hart, Pedro Coelho, Rafael Romero-Garcia, Alexa McDonald, Emma Woodberry, Robert C. Morris, Stephen J. Price, John Suckling, Thomas Santarius, John Duncan, Yaara Erez

Research output: Contribution to journalArticlepeer-review

Abstract

Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest fine-grained distinctions within this region. To examine this question electrophysiologically, we placed electrodes on the lateral frontal cortex in patients undergoing awake craniotomy for tumor resection. Patients performed verbal tasks with a manipulation of attentional switching, a canonical control demand. Power in the high gamma range (70–250 Hz) distinguished electrodes based on their location within a high-resolution fMRI network parcellation of the frontal lobe. Electrodes within the canonical fronto-parietal control network showed increased power in the switching condition, a result absent in electrodes within default mode, language and somato-motor networks. High gamma results contrasted with spatially distributed power decreases in the beta range (12–30 Hz). These results confirm the importance of fine-scale functional distinctions within the human frontal lobe, and pave the way for increased precision of functional mapping in tumor surgeries.

Original languageEnglish
Pages (from-to)286-298
Number of pages13
JournalCortex
Volume159
DOIs
StatePublished - Feb 2023

Keywords

  • Cognitive control
  • ECoG
  • Electrocorticography
  • Fronto-parietal
  • High gamma
  • Intracranial EEG
  • Intraoperative
  • fMRI
  • iEEG

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience

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