TY - GEN
T1 - Hemorrhage control by short electrical pulses- In vivo experiments
AU - Barnea, Ofer
AU - Mandel, Yossi
PY - 2012
Y1 - 2012
N2 - An internal hemorrhagic shock is one of the leading causes of death in the battlefield and other trauma events. However the application of direct pressure, as in the treatment of an external hemorrhage, is not possible. Most common techniques to achieve vasoconstriction are through heat; yet heating causes irreversible destruction of organ tissues. Therefore, there is a need for a non-thermal based technology for hemorrhage control. The current research describes, for the first, an attempt to reduce the amount of bleeding in animal model liver injuries by using electrical pulses treatment (EPT). In the experiments, which were performed on 28 rats and 14 rabbits, a short (25μs and 50μs) EPT was applied to the treatment groups and the amount of bleeding was compared to the non-treatment (NT) groups. A reduction of 60%, 36% and 44% in blood volume, was found in the 25μs-rats, 50μs-rats and 25μs-rabbits EPT groups, respectively (P<0.001). Also, it was found that the hemorrhage control was not caused by the mechanical pressure applied by the electrodes, and there was no evidence for thermal coagulation. Further research is needed to fully expose the potential of this treatment and the modality for hemorrhage control in civilian and military settings.
AB - An internal hemorrhagic shock is one of the leading causes of death in the battlefield and other trauma events. However the application of direct pressure, as in the treatment of an external hemorrhage, is not possible. Most common techniques to achieve vasoconstriction are through heat; yet heating causes irreversible destruction of organ tissues. Therefore, there is a need for a non-thermal based technology for hemorrhage control. The current research describes, for the first, an attempt to reduce the amount of bleeding in animal model liver injuries by using electrical pulses treatment (EPT). In the experiments, which were performed on 28 rats and 14 rabbits, a short (25μs and 50μs) EPT was applied to the treatment groups and the amount of bleeding was compared to the non-treatment (NT) groups. A reduction of 60%, 36% and 44% in blood volume, was found in the 25μs-rats, 50μs-rats and 25μs-rabbits EPT groups, respectively (P<0.001). Also, it was found that the hemorrhage control was not caused by the mechanical pressure applied by the electrodes, and there was no evidence for thermal coagulation. Further research is needed to fully expose the potential of this treatment and the modality for hemorrhage control in civilian and military settings.
KW - Electrical Pulses
KW - Hemorrhage Control
KW - Liver Injury
UR - http://www.scopus.com/inward/record.url?scp=84871983323&partnerID=8YFLogxK
U2 - https://doi.org/10.1109/EEEI.2012.6377126
DO - https://doi.org/10.1109/EEEI.2012.6377126
M3 - منشور من مؤتمر
SN - 9781467346801
T3 - 2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012
BT - 2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012
T2 - 2012 IEEE 27th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2012
Y2 - 14 November 2012 through 17 November 2012
ER -