Hemorrhage control by microsecond electrical pulses

Yossi Mandel, Richard Manivanh, Roopa Dalal, Phil Huie, Jenny Wang, Mark Brinton, Daniel Palanker

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Non-compressible hemorrhages are the most common preventable cause of death on battlefield or in civilian traumatic injuries. We report the use of sub-millisecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Extent of vascular constriction could be modulated by pulse duration, amplitude and repetition rate. Electrically-induced vasoconstriction could be maintained at steady level until the end of stimulation, and blood vessels dilated back to their original size within a few minutes after the end of stimulation. At higher settings, a blood clotting could be introduced, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.

Original languageEnglish
Title of host publicationTerahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications
StatePublished - 2013
Externally publishedYes
EventTerahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications - San Francisco, CA, United States
Duration: 6 Feb 20137 Feb 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE


ConferenceTerahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications
Country/TerritoryUnited States
CitySan Francisco, CA


  • blood vessel
  • electric pulse
  • hemorrhage
  • trauma

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


Dive into the research topics of 'Hemorrhage control by microsecond electrical pulses'. Together they form a unique fingerprint.

Cite this