@inproceedings{db7a8b171283432abec980b9523f01b8,
title = "Hemodynamic and morphologic responses in mouse brain during acute head injury imaged by multispectral structured illumination",
abstract = "Multispectral imaging has received significant attention over the last decade as it integrates spectroscopy, imaging, tomography analysis concurrently to acquire both spatial and spectral information from biological tissue. In the present study, a multispectral setup based on projection of structured illumination at several near-infrared wavelengths and at different spatial frequencies is applied to quantitatively assess brain function before, during, and after the onset of traumatic brain injury in an intact mouse brain (n=5). For the production of head injury, we used the weight drop method where weight of a cylindrical metallic rod falling along a metal tube strikes the mouse's head. Structured light was projected onto the scalp surface and diffuse reflected light was recorded by a CCD camera positioned perpendicular to the mouse head. Following data analysis, we were able to concurrently show a series of hemodynamic and morphologic changes over time including higher deoxyhemoglobin, reduction in oxygen saturation, cell swelling, etc., in comparison with baseline measurements. Overall, results demonstrates the capability of multispectral imaging based structured illumination to detect and map of brain tissue optical and physiological properties following brain injury in a simple noninvasive and noncontact manner.",
keywords = "Cerebral hemodynamics, Diffuse reflectance, Head injury, Multispectral imaging, Optical properties, Structured illumination",
author = "Boris Volkov and Mathews, {Marlon S.} and David Abookasis",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II ; Conference date: 07-02-2015 Through 10-02-2015",
year = "2015",
month = jan,
day = "1",
doi = "https://doi.org/10.1117/12.2078711",
language = "الإنجليزيّة",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Henry Hirschberg and Madsen, {Steen J.} and Qingming Luo and Mohanty, {Samarendra K.} and Thakor, {Nitish V.} and Jansen, {E. Duco}",
booktitle = "Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II",
address = "الولايات المتّحدة",
}