Heartworm adulticide treatment: a tropical perspective

Filipe Dantas-Torres; Jennifer Ketzis; Gabriela Pérez Tort; Andrei Daniel Mihalca; Gad Baneth; Domenico Otranto; Malaika Watanabe; Bui Khanh Linh; Tawin Inpankaew; Pablo Borrás; Sangaran Arumugam; Barend Louis Penzhorn; Adrian Patalinghug Ybañez; Peter Irwin; Rebecca J. Traub

doi:10.1186/s13071-023-05690-8

Heartworm adulticide treatment: a tropical perspective

Filipe Dantas-Torres, Jennifer Ketzis, Gabriela Pérez Tort, Andrei Daniel Mihalca, Gad Baneth, Domenico Otranto, Malaika Watanabe, Bui Khanh Linh, Tawin Inpankaew, Pablo Borrás, Sangaran Arumugam, Barend Louis Penzhorn, Adrian Patalinghug Ybañez, Peter Irwin, Rebecca J. Traub

The Koret School of Veterinary Medicine

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English
Article number	148
Journal	Parasites and Vectors
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s13071-023-05690-8
State	Published - Dec 2023

Keywords

Dirofilaria immitis
Doxycycline
Ivermectin
Melarsomine
Mosquitoes
Moxidectin
One health
Prevention

All Science Journal Classification (ASJC) codes

Infectious Diseases
General Veterinary
Parasitology

Access to Document

10.1186/s13071-023-05690-8

Cite this

@article{83006b5157154d8da4574b125214ac92,

title = "Heartworm adulticide treatment: a tropical perspective",

abstract = "Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.]",

keywords = "Dirofilaria immitis, Doxycycline, Ivermectin, Melarsomine, Mosquitoes, Moxidectin, One health, Prevention",

author = "Filipe Dantas-Torres and Jennifer Ketzis and {P{\'e}rez Tort}, Gabriela and Mihalca, {Andrei Daniel} and Gad Baneth and Domenico Otranto and Malaika Watanabe and Linh, {Bui Khanh} and Tawin Inpankaew and Pablo Borr{\'a}s and Sangaran Arumugam and Penzhorn, {Barend Louis} and Yba{\~n}ez, {Adrian Patalinghug} and Peter Irwin and Traub, {Rebecca J.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1186/s13071-023-05690-8",

language = "الإنجليزيّة",

volume = "16",

journal = "Parasites and Vectors",

issn = "1756-3305",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Heartworm adulticide treatment

T2 - a tropical perspective

AU - Dantas-Torres, Filipe

AU - Ketzis, Jennifer

AU - Pérez Tort, Gabriela

AU - Mihalca, Andrei Daniel

AU - Baneth, Gad

AU - Otranto, Domenico

AU - Watanabe, Malaika

AU - Linh, Bui Khanh

AU - Inpankaew, Tawin

AU - Borrás, Pablo

AU - Arumugam, Sangaran

AU - Penzhorn, Barend Louis

AU - Ybañez, Adrian Patalinghug

AU - Irwin, Peter

AU - Traub, Rebecca J.

PY - 2023/12

Y1 - 2023/12

N2 - Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.]

AB - Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.]

KW - Dirofilaria immitis

KW - Doxycycline

KW - Ivermectin

KW - Melarsomine

KW - Mosquitoes

KW - Moxidectin

KW - One health

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=85156210900&partnerID=8YFLogxK

U2 - 10.1186/s13071-023-05690-8

DO - 10.1186/s13071-023-05690-8

M3 - مقالة مرجعية

C2 - 37106364

SN - 1756-3305

VL - 16

JO - Parasites and Vectors

JF - Parasites and Vectors

IS - 1

M1 - 148

ER -

Heartworm adulticide treatment: a tropical perspective

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this