Harnessing the power of IFN for therapeutic approaches to COVID-19

Viox Elise G.; Bosinger Steven E.; Douek Daniel C.; Schreiber Gideon; Paiardini Mirko

doi:10.1128/jvi.01204-23

Harnessing the power of IFN for therapeutic approaches to COVID-19

Viox Elise G.
, Bosinger Steven E.
, Douek Daniel C.
, Schreiber Gideon
, Paiardini Mirko

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

Original language	English
Article number	e01204-23
Number of pages	15
Journal	Journal of Virology
Volume	98
Issue number	5
Early online date	23 Apr 2024
DOIs	https://doi.org/10.1128/jvi.01204-23
State	Published - 14 May 2024

ASJC Scopus subject areas

Immunology
Microbiology
Insect Science
Virology

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10.1128/jvi.01204-23

Cite this

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title = "Harnessing the power of IFN for therapeutic approaches to COVID-19",

abstract = "Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.",

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AU - Gideon, Schreiber

AU - Mirko, Paiardini

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AB - Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

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U2 - 10.1128/jvi.01204-23

DO - 10.1128/jvi.01204-23

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JO - Journal of Virology

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Harnessing the power of IFN for therapeutic approaches to COVID-19

Abstract

ASJC Scopus subject areas

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