Harnessing the power of IFN for therapeutic approaches to COVID-19

Viox Elise G.; Bosinger Steven E.; Douek Daniel C.; Schreiber Gideon; Paiardini Mirko

doi:10.1128/jvi.01204-23

Harnessing the power of IFN for therapeutic approaches to COVID-19

Viox Elise G., Bosinger Steven E., Douek Daniel C., Schreiber Gideon, Paiardini Mirko

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

Original language	English
Article number	e01204-23
Journal	Journal of Virology
Volume	98
Issue number	5
DOIs	https://doi.org/10.1128/jvi.01204-23
State	Published Online - 23 Apr 2024

All Science Journal Classification (ASJC) codes

Insect Science
Virology
Microbiology
Immunology

Access to Document

10.1128/jvi.01204-23

Cite this

@article{354093de45974be7882fe91b4e696195,

title = "Harnessing the power of IFN for therapeutic approaches to COVID-19",

abstract = "Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.",

author = "G., {Viox Elise} and E., {Bosinger Steven} and C., {Douek Daniel} and Schreiber Gideon and Paiardini Mirko",

note = "This work was supported by P510D011132-60S4: COVTEN/ACTIV, the Emory MP3 Grant, Fast Grants #2144, and the Pitts Foundation. Figures 1 and 2 were created with BioRender.com. E.G.V. and M.P. wrote the manuscript with critical inputs from S.E.B., D.C.D., and G.S.",

year = "2024",

month = apr,

day = "23",

doi = "10.1128/jvi.01204-23",

language = "الإنجليزيّة",

volume = "98",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Harnessing the power of IFN for therapeutic approaches to COVID-19

AU - G., Viox Elise

AU - E., Bosinger Steven

AU - C., Douek Daniel

AU - Gideon, Schreiber

AU - Mirko, Paiardini

N1 - This work was supported by P510D011132-60S4: COVTEN/ACTIV, the Emory MP3 Grant, Fast Grants #2144, and the Pitts Foundation. Figures 1 and 2 were created with BioRender.com. E.G.V. and M.P. wrote the manuscript with critical inputs from S.E.B., D.C.D., and G.S.

PY - 2024/4/23

Y1 - 2024/4/23

N2 - Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

AB - Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

UR - http://www.scopus.com/inward/record.url?scp=85193099284&partnerID=8YFLogxK

U2 - 10.1128/jvi.01204-23

DO - 10.1128/jvi.01204-23

M3 - مقالة

C2 - 38651899

SN - 0022-538X

VL - 98

JO - Journal of Virology

JF - Journal of Virology

IS - 5

M1 - e01204-23

ER -

Harnessing the power of IFN for therapeutic approaches to COVID-19

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this