Haploidentical hematopoietic transplantation: current status and future perspectives

Yair Reisner, David Hagin, Massimo F. Martelli

Research output: Contribution to journalReview articlepeer-review


For patients with hematologic malignancies at high risk of relapse who do not have matched donors, a suitable alternative stem cell source is the HLA-haploidentical 2 or 3-loci mismatched family donor who is readily available for nearly all patients. Transplantation across the major HLA barrier is associated with strong T-cell alloreactions, which were originally manifested as a high incidence of severe GVHD and graft rejection. The present review shows how these obstacles to successful transplantation were overcome in the last 15 years, making full haplotype-mismatched transplantation a clinical reality that provides similar outcomes to transplantation from matched unrelated donors. The review also discusses the advantages and drawbacks of current options for full haplotype-mismatched transplantation and highlights innovative approaches for rebuilding immunity after transplantation and improving survival. (Blood. 2011;118(23):6006-6017)
Original languageEnglish
Pages (from-to)6006-6017
Number of pages12
Issue number23
StatePublished - Dec 2011


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