Haemocompatibility of modified nanodiamonds

Michal Wasowicz, Mateusz Ficek, Maciej S. Wróbel, Ruchira Chakraborty, Dror Fixler, Pawel Wierzba, Malgorzata Jȩdrzejewska-Szczerska

Research output: Contribution to journalArticlepeer-review

Abstract

This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds. Specific modifications of the nanodiamonds give us the possibility to obtain nanoparticles which are biocompatible with human blood. They can form a basis for the development of nanoscale biomarkers and parts of sensing systems and devices useful in biomedical environments.

Original languageEnglish
Article number352
JournalMaterials
Volume10
Issue number4
DOIs
StatePublished - 28 Mar 2017

Keywords

  • Biophotonics
  • Blood
  • Haemocompatibility
  • Nanodiamonds
  • Spectroscopy

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • General Materials Science

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