H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

R. Gersner; L. Oberman; M. J. Sanchez; N. Chiriboga; H. L. Kaye; A. Pascual-Leone; M. Libenson; Y. Roth; A. Zangen; A. Rotenberg

doi:https://doi.org/10.1016/j.ebcr.2016.03.001

H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

R. Gersner, L. Oberman, M. J. Sanchez, N. Chiriboga, H. L. Kaye, A. Pascual-Leone, M. Libenson, Y. Roth, A. Zangen, A. Rotenberg

Department of Life Sciences

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial cortical areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), is possible using specially designed H-coils. We report the results of rTMS in a young adult with pharmacoresistant bilateral TLE who underwent three courses (of 10, 15, and 30 daily sessions) of unilateral rTMS over the hemisphere from which seizures originated most often. Seizure frequency was assessed before and after each block of rTMS sessions, as was the tolerability of the procedure. Seizure frequency declined significantly, by 50 to 70% following each rTMS course. All sessions were well-tolerated.

Original language	American English
Pages (from-to)	52-56
Number of pages	5
Journal	Epilepsy and Behavior Case Reports
Volume	5
DOIs	https://doi.org/10.1016/j.ebcr.2016.03.001
State	Published - 1 Jan 2016

Keywords

Epilepsy
Neuromodulation
Transcranial magnetic stimulation

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Behavioral Neuroscience

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https://doi.org/10.1016/j.ebcr.2016.03.001

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title = "H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report",

abstract = "Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial cortical areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), is possible using specially designed H-coils. We report the results of rTMS in a young adult with pharmacoresistant bilateral TLE who underwent three courses (of 10, 15, and 30 daily sessions) of unilateral rTMS over the hemisphere from which seizures originated most often. Seizure frequency was assessed before and after each block of rTMS sessions, as was the tolerability of the procedure. Seizure frequency declined significantly, by 50 to 70% following each rTMS course. All sessions were well-tolerated.",

keywords = "Epilepsy, Neuromodulation, Transcranial magnetic stimulation",

author = "R. Gersner and L. Oberman and Sanchez, {M. J.} and N. Chiriboga and Kaye, {H. L.} and A. Pascual-Leone and M. Libenson and Y. Roth and A. Zangen and A. Rotenberg",

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doi = "https://doi.org/10.1016/j.ebcr.2016.03.001",

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T1 - H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy

T2 - A case report

AU - Gersner, R.

AU - Oberman, L.

AU - Sanchez, M. J.

AU - Chiriboga, N.

AU - Kaye, H. L.

AU - Pascual-Leone, A.

AU - Libenson, M.

AU - Roth, Y.

AU - Zangen, A.

AU - Rotenberg, A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial cortical areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), is possible using specially designed H-coils. We report the results of rTMS in a young adult with pharmacoresistant bilateral TLE who underwent three courses (of 10, 15, and 30 daily sessions) of unilateral rTMS over the hemisphere from which seizures originated most often. Seizure frequency was assessed before and after each block of rTMS sessions, as was the tolerability of the procedure. Seizure frequency declined significantly, by 50 to 70% following each rTMS course. All sessions were well-tolerated.

AB - Low frequency repetitive TMS (rTMS) of a cortical seizure focus is emerging as an antiepileptic treatment. While conventional rTMS stimulators activate only superficial cortical areas, reaching deep epileptic foci, for example in temporal lobe epilepsy (TLE), is possible using specially designed H-coils. We report the results of rTMS in a young adult with pharmacoresistant bilateral TLE who underwent three courses (of 10, 15, and 30 daily sessions) of unilateral rTMS over the hemisphere from which seizures originated most often. Seizure frequency was assessed before and after each block of rTMS sessions, as was the tolerability of the procedure. Seizure frequency declined significantly, by 50 to 70% following each rTMS course. All sessions were well-tolerated.

KW - Epilepsy

KW - Neuromodulation

KW - Transcranial magnetic stimulation

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U2 - https://doi.org/10.1016/j.ebcr.2016.03.001

DO - https://doi.org/10.1016/j.ebcr.2016.03.001

M3 - Article

C2 - 27114902

SN - 2213-3232

VL - 5

SP - 52

EP - 56

JO - Epilepsy and Behavior Case Reports

JF - Epilepsy and Behavior Case Reports

ER -

H-coil repetitive transcranial magnetic stimulation for treatment of temporal lobe epilepsy: A case report

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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