The densely-populated Haifa Bay region is the main petrochemical hub of Israel. The seismic hazard of this area is elevated due to the proximity of active tectonic borders (Dead Sea Transform) and underlying sedimentary basin. Here we describe the results of two independent and complementing approaches to estimate ground motion amplification of this region. We report the results of seismic monitoring campaign using a transportable network deployed atop the sedimentary basin and adjacent rock site. We also report the results of a numeric wave propagation modeling using high-resolution geological model. Instrumental spectral ratios show that over the deepest parts of the sedimentary basin, and the location of main industrial hub, low frequency (< 1 Hz) amplification factors are up to a value of 8. Numerical amplification ratio maps of the entire region show comparable, to instrumental, amplification factors for low frequencies (< 0.75 Hz) and allow micro-zonation of seismic hazard of the Haifa Bay region.