Abstract
Gold catalyzed cycloisomerization of aromatic ring tethered vinylidenecyclopropane-enes provides a divergent synthetic protocol for the construction of O-containing fused heterocycles through controllable carbene or non-carbene related processes. The carbene induced process features a new amphiphilic strategy to generate a gold carbene via a rearrangement of vinylidenecyclopropane. Whereas, the electronic effect of the ortho-substituents switches the reaction mode onto the non-carbene related process, from which five- or six-membered rings are selectively produced through allyl-migration.
Original language | English |
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Pages (from-to) | 5519-5525 |
Number of pages | 7 |
Journal | Chemical Science |
Volume | 6 |
Issue number | 10 |
DOIs | |
State | Published - 23 Jun 2015 |
All Science Journal Classification (ASJC) codes
- General Chemistry