Gold nanoparticles for enhanced delivery of chemotherapy

Idan Katzir; Yoray Sharon; Tamar Sadan; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.3005422

Gold nanoparticles for enhanced delivery of chemotherapy

Idan Katzir
, Yoray Sharon
, Tamar Sadan
, Menachem Motiei
, Rachela Popovtzer

Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI
Editors	Dror Fixler, Sebastian Wachsmann-Hogiu
Publisher	SPIE
ISBN (Electronic)	9781510669758
DOIs	https://doi.org/10.1117/12.3005422
State	Published - 2024
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024 - San Francisco, United States Duration: 28 Jan 2024 → …

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12858

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024
Country/Territory	United States
City	San Francisco
Period	28/01/24 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
chemotherapy
gold nanoparticles.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.3005422

Cite this

Katzir, I., Sharon, Y., Sadan, T., Motiei, M., & Popovtzer, R. (2024). Gold nanoparticles for enhanced delivery of chemotherapy. In D. Fixler, & S. Wachsmann-Hogiu (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI Article 128580C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12858). SPIE. https://doi.org/10.1117/12.3005422

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title = "Gold nanoparticles for enhanced delivery of chemotherapy",

abstract = "Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.",

keywords = "Cancer, chemotherapy, gold nanoparticles.",

author = "Idan Katzir and Yoray Sharon and Tamar Sadan and Menachem Motiei and Rachela Popovtzer",

note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024 ; Conference date: 28-01-2024",

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doi = "10.1117/12.3005422",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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Katzir, I, Sharon, Y, Sadan, T, Motiei, M & Popovtzer, R 2024, Gold nanoparticles for enhanced delivery of chemotherapy. in D Fixler & S Wachsmann-Hogiu (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI., 128580C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12858, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024, San Francisco, United States, 28/01/24. https://doi.org/10.1117/12.3005422

Gold nanoparticles for enhanced delivery of chemotherapy. / Katzir, Idan; Sharon, Yoray; Sadan, Tamar et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI. ed. / Dror Fixler; Sebastian Wachsmann-Hogiu. SPIE, 2024. 128580C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12858).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Gold nanoparticles for enhanced delivery of chemotherapy

AU - Katzir, Idan

AU - Sharon, Yoray

AU - Sadan, Tamar

AU - Motiei, Menachem

AU - Popovtzer, Rachela

PY - 2024

Y1 - 2024

N2 - Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.

AB - Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.

KW - Cancer

KW - chemotherapy

KW - gold nanoparticles.

UR - https://www.scopus.com/pages/publications/85191523233

U2 - 10.1117/12.3005422

DO - 10.1117/12.3005422

M3 - Conference contribution

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI

A2 - Fixler, Dror

A2 - Wachsmann-Hogiu, Sebastian

PB - SPIE

T2 - Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024

Y2 - 28 January 2024

ER -

Gold nanoparticles for enhanced delivery of chemotherapy

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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