Goblet and Paneth Cells: Producers of the Intestinal Barrier

Sonia Modilevsky; Maria Naama; Shai Bel

doi:https://doi.org/10.1016/b978-0-12-821618-7.00140-1

Goblet and Paneth Cells: Producers of the Intestinal Barrier

Sonia Modilevsky, Maria Naama, Shai Bel

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The mammalian intestine is colonized by trillions of microbes. To maintain a symbiotic relationship with these microbes the host creates a chemical barrier between itself and the gut microbiota. This barrier enables a mutually beneficial interaction while limiting microbial invasion into host tissues. The main components of this barrier are mucus and antimicrobial proteins which are secreted from two specialized types of epithelial cells, goblet and Paneth cells. Here, we will discuss the function of these two cell types and explain how they maintain intestinal homeostasis and their role in intestinal inflammation.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	66-71
Number of pages	6
Volume	6
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/b978-0-12-821618-7.00140-1
State	Published - 1 Jan 2022

Keywords

Antimicrobial
Crohn’s disease
Goblet
Gut
Host defense
Inflammatory bowel diseases
Intestine
Microbiome
Microbiota
Mucus
Paneth
Ulcerative colitis

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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Cite this

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KW - Host defense

KW - Inflammatory bowel diseases

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KW - Microbiome

KW - Microbiota

KW - Mucus

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KW - Ulcerative colitis

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PB - Elsevier

ER -

Goblet and Paneth Cells: Producers of the Intestinal Barrier

Abstract

Keywords

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