Glucosylated Polymeric Micelles Actively Target a Breast Cancer Model

Nicole Lecot, Romina Glisoni, Natalia Oddone, Juan Benech, Marcelo Fernández, Juan Pablo Gambini, Pablo Cabral, Alejandro Sosnik

Research output: Contribution to journalArticlepeer-review


This work investigates the potential of glycosylation to actively target nanodrug delivery systems to adult solid tumors overexpressing glucose transporters. The highly hydrophobic fluorescent compound curcumin (CUR) is nanoencapsulated within polymeric micelles of pristine and glucosylated poly(ethylene oxide)-poly(propylene oxide) block copolymers, and their interaction with breast cancer (BC) cells is investigated in vitro and in vivo. The aqueous solubility of CUR is increased more than 50 000-fold and spherical nanoparticles display size in the 40 to 500 nm range, as determined by transmission electron microscopy and by dynamic light scattering, respectively. Uptake studies conducted in the BC cell line 4T1 in vitro demonstrate that glucosylation enhances nanoparticle internalization. Finally, the ability of unmodified and glucosylated polymeric micelles to accumulate in female BALB/c mice bearing 4T1-induced tumors is compared by ex vivo bioimaging with auspicious results.

Original languageEnglish
Article number2000010
JournalAdvanced Therapeutics
Issue number1
StatePublished - Jan 2021


  • breast cancer
  • curcumin
  • glucosylated polymeric micelles
  • intratumoral accumulation
  • poly(ethylene oxide)-b-poly(propylene oxide) block copolymers

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, medical
  • Pharmacology (medical)
  • Genetics(clinical)
  • Pharmaceutical Science
  • Pharmacology


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