@inproceedings{787b11756ae14b7cb1e4a82db41b2bf9,
title = "Glucose-functionalized gold nanoparticles as a metabolically targeted CT contrast agent for distinguishing tumors from non-malignant metabolically active processes",
abstract = "The highly used cancer imaging technique, [18F]FDG-PET, is based on the increased glucose metabolic activity in tumors. However, since there are other biological processes that exhibit increased metabolic activity, in particular inflammation, this methodology is prone to non-specificity for cancer. Herein we describe the development of a novel nanoparticle-based approach, utilizes Glucose-Functionalized Gold Nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our method has demonstrated specific tumor targeting and has successfully differentiated between cancer and inflammation in a combined tumor-inflammation mouse model, due to dissimilarities in vasculatures in different pathologic conditions. This novel approach provides new capabilities in cancer imaging, and can be applicable to a wide range of cancers.",
keywords = "CT, Cancer, FDG-PET, Gold nanoparticles, Metabolic-based imaging",
author = "Tamar Dreifuss and Menachem Motiei and Oshra Betzer and Aron Popovtzer and Galith Abourbeh and Eyal Mishani and Rachela Popovtzer",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017 ; Conference date: 30-01-2017 Through 01-02-2017",
year = "2017",
doi = "https://doi.org/10.1117/12.2249850",
language = "الإنجليزيّة",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Nicolau, {Dan V.} and Dror Fixler and Cartwright, {Alexander N.}",
booktitle = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV",
address = "الولايات المتّحدة",
}