TY - GEN
T1 - Geometric Interpretation of Gene Expression by Sparse Reconstruction of Transcript Profiles
AU - Prat, Yosef
AU - Fromer, Menachem
AU - Linial, Michal
AU - Linial, Nathan
N1 - Publisher Copyright: © 2011, Springer-Verlag Berlin Heidelberg.
PY - 2011
Y1 - 2011
N2 - Large-scale data collection technologies have come to play a central role in biological and biomedical research in the last decade. Consequently, it has become a major goal of functional genomics to develop, based on such data, a comprehensive description of the functions and interactions of all genes and proteins in a genome. Most large-scale biological data, including gene expression profiles, are usually represented by a matrix, where n genes are examined in d experiments. Here, we view such data as a set of n points (vectors) in d-dimensional space, each of which represents the profile of a given gene over d different experimental conditions. Many known methods that have yielded meaningful biological insights seek geometric or algebraic features of these vectors.
AB - Large-scale data collection technologies have come to play a central role in biological and biomedical research in the last decade. Consequently, it has become a major goal of functional genomics to develop, based on such data, a comprehensive description of the functions and interactions of all genes and proteins in a genome. Most large-scale biological data, including gene expression profiles, are usually represented by a matrix, where n genes are examined in d experiments. Here, we view such data as a set of n points (vectors) in d-dimensional space, each of which represents the profile of a given gene over d different experimental conditions. Many known methods that have yielded meaningful biological insights seek geometric or algebraic features of these vectors.
UR - http://www.scopus.com/inward/record.url?scp=79953206239&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-3-642-20036-6_33
DO - https://doi.org/10.1007/978-3-642-20036-6_33
M3 - منشور من مؤتمر
SN - 9783642200359
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 355
EP - 357
BT - Research in Computational Molecular Biology - 15th Annual International Conference, RECOMB 2011, Proceedings
A2 - Bafna, Vineet
A2 - Sahinalp, S. Cenk
T2 - 15th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2011
Y2 - 28 March 2011 through 31 March 2011
ER -