Genomically recoded organisms: redefining and safeguarding biological systems

Miriam Amiram

doi:10.1016/j.tibtech.2025.03.014

Genomically recoded organisms: redefining and safeguarding biological systems

Miriam Amiram

Department of Biotechnology Engineering

Ben-Gurion University of the Negev

Research output: Contribution to journal › Short survey › peer-review

Abstract

In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.

Original language	American English
Journal	Trends in Biotechnology
DOIs	https://doi.org/10.1016/j.tibtech.2025.03.014
State	Accepted/In press - 1 Jan 2025

Keywords

biocontainment
genomically recoded organisms
noncanonical amino acids
orthogonal translation machinery

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering

Access to Document

10.1016/j.tibtech.2025.03.014

Cite this

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abstract = "In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.",

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AB - In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.

KW - biocontainment

KW - genomically recoded organisms

KW - noncanonical amino acids

KW - orthogonal translation machinery

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JO - Trends in Biotechnology

JF - Trends in Biotechnology

ER -

Genomically recoded organisms: redefining and safeguarding biological systems

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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