Genome maintenance in pluripotent stem cells

Uri Weissbein; Nissim Benvenisty; Uri Ben-David

doi:10.1083/jcb.201310135

Genome maintenance in pluripotent stem cells

Uri Weissbein, Nissim Benvenisty, Uri Ben-David

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.

Original language	English
Pages (from-to)	153-163
Number of pages	11
Journal	Journal of Cell Biology
Volume	204
Issue number	2
DOIs	https://doi.org/10.1083/jcb.201310135
State	Published - 20 Jan 2014

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1083/jcb.201310135

Cite this

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abstract = "Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.",

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AB - Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.

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DO - 10.1083/jcb.201310135

M3 - مقالة مرجعية

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JO - Journal of Cell Biology

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Genome maintenance in pluripotent stem cells

Abstract

All Science Journal Classification (ASJC) codes

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