Generating an inhomogeneous stress field as a technique to study cell mechanoresponse

D. Raz-Ben Aroush, D. Barlam, H. Daniel Wagner

Research output: Contribution to journalArticlepeer-review


Over the last decade, it has been shown that cells can sense and respond to mechanical perturbations in their underlying substrate (or extra-cellular matrix, ECM). However, the effect of an inhomogeneous stress on cell response has been scarcely studied, mainly due to technical difficulty to create a well-controlled stress (or strain) state in the ECM, even though stress gradients are of critical importance in-and likely induce-wound healing, for example, through local cell growth and tissue formation. Here, we present a technique which can be easily used to study the response behavior of cells to a well-defined inhomogeneous stress field.

Original languageEnglish
Article number133703
Number of pages4
JournalApplied Physics Letters
Issue number13
StatePublished - 26 Mar 2012

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)


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