Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev; Sheera Adar; Yi Ying Chiou; Jason D. Lieb; Aziz Sancar; Rui Ye

doi:10.1074/jbc.M113.534651

Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev, Sheera Adar, Yi Ying Chiou, Jason D. Lieb, Aziz Sancar, Rui Ye

Department of Microbiology and Molecular Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

Original language	English
Pages (from-to)	5013-5024
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.534651
State	Published - 21 Feb 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.",

author = "Yunus Annayev and Sheera Adar and Chiou, \{Yi Ying\} and Lieb, \{Jason D.\} and Aziz Sancar and Rui Ye",

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doi = "10.1074/jbc.M113.534651",

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AU - Adar, Sheera

AU - Chiou, Yi Ying

AU - Lieb, Jason D.

AU - Sancar, Aziz

AU - Ye, Rui

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

AB - Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

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DO - 10.1074/jbc.M113.534651

M3 - مقالة

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Abstract

All Science Journal Classification (ASJC) codes

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