Gene expression associated with early and late chronotypes in Drosophila melanogaster

Mirko Pegoraro, Emma Picot, Celia N. Hansen, Charalambos P. Kyriacou, Ezio Rosato, Eran Tauber

Research output: Contribution to journalArticlepeer-review


The circadian clock provides the temporal framework for rhythmic behavioral and metabolic functions. In the modern era of industrialization, work, and social pressures, clock function is jeopardized, and can result in adverse and chronic effects on health. Understanding circadian clock function, particularly individual variation in diurnal phase preference (chronotype), and the molecular mechanisms underlying such chronotypes may lead to interventions that could abrogate clock dysfunction and improve human (and animal) health and welfare. Our preliminary studies suggested that fruit-flies, like humans, can be classified as early rising "larks" or late rising "owls," providing a convenient model system for these types of studies. We have identified strains of flies showing increased preference for morning emergence (Early or E) from the pupal case, or more pronounced preference for evening emergence (Late or L). We have sampled pupae the day before eclosion (fourth day after pupariation) at 4 h intervals in the E and L strains, and examined differences in gene expression by RNA-seq. We have identified differentially expressed transcripts between the E and L strains, which provide candidate genes for subsequent studies of Drosophila chronotypes and their human orthologs.

Original languageAmerican English
Article number00100
JournalFrontiers in Neurology
Issue numberMAY
StatePublished - 2015
Externally publishedYes


  • Chronotype
  • Circadian clock
  • Drosophila
  • Eclosion
  • Transcriptomics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology


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