Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich; M. Salti; S. D. Goren; E. B. Yudina; A. E. Aleksenskii; A. Ya Vul; A. I. Shames

doi:10.1021/acs.jpcc.8b11655

Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich, M. Salti, S. D. Goren, E. B. Yudina, A. E. Aleksenskii, A. Ya Vul, A. I. Shames

Department of Physics

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the first ¹H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T₁) and spin-spin (T₂) relaxation times of water protons providing relaxivities of r₁ = 33.4 and r₂ = 332 mM^-1 s^-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

Original language	American English
Pages (from-to)	2627-2631
Number of pages	5
Journal	Journal of Physical chemistry c
Volume	123
Issue number	4
DOIs	https://doi.org/10.1021/acs.jpcc.8b11655
State	Published - 31 Jan 2019

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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title = "Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement",

abstract = "We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.",

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doi = "10.1021/acs.jpcc.8b11655",

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T1 - Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

AU - Panich, A. M.

AU - Salti, M.

AU - Goren, S. D.

AU - Yudina, E. B.

AU - Aleksenskii, A. E.

AU - Vul, A. Ya

AU - Shames, A. I.

PY - 2019/1/31

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N2 - We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

AB - We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

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Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

Abstract

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