Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

A. M. Panich, M. Salti, S. D. Goren, E. B. Yudina, A. E. Aleksenskii, A. Ya Vul, A. I. Shames

Research output: Contribution to journalArticlepeer-review


We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd(III) ions. In contrast to Gd(III)-ND conjugates implemented via organic species, Gd(III) ions were directly grafted to the surface of DND particles. Such Gd(III)-grafted DND particles significantly shorten spin-lattice (T1) and spin-spin (T2) relaxation times of water protons providing relaxivities of r1 = 33.4 and r2 = 332 mM-1 s-1, which considerably exceed most of those reported in the literature. It makes the Gd(III)-grafted DND complexes attractive for use as novel MRI contrast agents.

Original languageAmerican English
Pages (from-to)2627-2631
Number of pages5
JournalJournal of Physical chemistry c
Issue number4
StatePublished - 31 Jan 2019

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Energy
  • Surfaces, Coatings and Films
  • Physical and Theoretical Chemistry


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