TY - JOUR
T1 - GABAergic Lateral Interactions Tune the Early Stages of Visual Processing in Drosophila
AU - Freifeld, Limor
AU - Clark, Damon A.
AU - Schnitzer, Mark J.
AU - Horowitz, Mark A.
AU - Clandinin, Thomas R.
N1 - Funding Information: The authors would like to thank Stephen Baccus, Saskia DeVries, Daryl Gohl, Marion Silles, Tina Schwab, Jennifer Esch, and Helen Yang for helpful comments on the manuscript. We would also like to thank Daryl Gohl and Xiaojing Gao (Luo laboratory) for providing fly stocks. This work was supported by a Fulbright Science and Technology Fellowship and a Bio-X Bruce and Elizabeth Dunlevie Stanford Interdisciplinary Graduate Fellowship (L.F.), a Jane Coffin Child’s Postdoctoral fellowship (D.A.C.), and a NIH Director’s Pioneer Award DP1 OD003530 (T.R.C.) and NIH R01EY022638 (T.R.C.).
PY - 2013/6/19
Y1 - 2013/6/19
N2 - Early stages of visual processing must capture complex, dynamic inputs. While peripheral neurons often implement efficient encoding by exploiting natural stimulus statistics, downstream neurons are specialized to extract behaviorally relevant features. How do these specializations ariseα We use two-photon imaging in Drosophila to characterize a first-order interneuron, L2, that provides input to a pathway specialized for detecting moving dark edges. GABAergic interactions, mediated in part presynaptically, create an antagonistic and anisotropic center-surround receptive field. This receptive field is spatiotemporally coupled, applying differential temporal processing to large and small dark objects, achieving significant specialization. GABAergic circuits also mediate OFF responses and balance these with responses to ON stimuli. Remarkably, the functional properties of L2 are strikingly similar to those of bipolar cells, yet emerge through different molecular and circuit mechanisms. Thus, evolution appears to have converged on a common strategy for processing visual information at the first synapse
AB - Early stages of visual processing must capture complex, dynamic inputs. While peripheral neurons often implement efficient encoding by exploiting natural stimulus statistics, downstream neurons are specialized to extract behaviorally relevant features. How do these specializations ariseα We use two-photon imaging in Drosophila to characterize a first-order interneuron, L2, that provides input to a pathway specialized for detecting moving dark edges. GABAergic interactions, mediated in part presynaptically, create an antagonistic and anisotropic center-surround receptive field. This receptive field is spatiotemporally coupled, applying differential temporal processing to large and small dark objects, achieving significant specialization. GABAergic circuits also mediate OFF responses and balance these with responses to ON stimuli. Remarkably, the functional properties of L2 are strikingly similar to those of bipolar cells, yet emerge through different molecular and circuit mechanisms. Thus, evolution appears to have converged on a common strategy for processing visual information at the first synapse
UR - http://www.scopus.com/inward/record.url?scp=84879250538&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neuron.2013.04.024
DO - https://doi.org/10.1016/j.neuron.2013.04.024
M3 - مقالة
SN - 0896-6273
VL - 78
SP - 1075
EP - 1089
JO - Neuron
JF - Neuron
IS - 6
ER -