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Fundamental Limits of Reference-Based Sequence Reordering

Nir Weinberger, Ilan Shomorony

Research output: Contribution to journalArticlepeer-review

Abstract

We consider the problem of reconstructing a sequence of independent and identically distributed symbols from a set of equal-size, consecutive, fragments, as well as a dependent reference sequence. First, in the regime in which the fragments are relatively long and typically no fragment appears more than once, we determine the scaling of the failure probability of the maximum-likelihood reconstruction algorithm for a perfect reconstruction, and bound it for a partial reconstruction. Second, we characterize the regime in which the fragments are relatively short and repeating fragments abound. We state a trade-off between the fraction of fragments that cannot be adequately reconstructed vs. the distortion level allowed for the reconstruction of each fragment, while still allowing vanishing failure probability.

Original languageEnglish
Article number10504879
Pages (from-to)1
Number of pages1
JournalIEEE Transactions on Information Theory
Volume70
Issue number7
DOIs
StatePublished - 1 Jul 2024

Keywords

  • DNA sequencing
  • Distortion
  • Encoding
  • Fragment reordering
  • Genomics
  • Noise measurement
  • Reconstruction algorithms
  • Sequential analysis
  • Vectors
  • bee-identification problem
  • permutation reconstruction
  • reference sequence
  • sequence reconstruction
  • side information
  • sliced sequences

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Library and Information Sciences
  • Computer Science Applications

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