Abstract
An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.
| Original language | American English |
|---|---|
| Patent number | WO2013183048 |
| IPC | C07K 7/08 2006.1, A61L 27/06 2006.1, A61C 8/00 2006.1 |
| Filing date | 6/06/13 |
| State | Published - 15 Aug 2017 |