Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Anna Devor; Sava Sakadžić; Mohammad A. Yaseen; Emmanuel Roussakis; Peifang Tian; Hamutal Slovin; Ivo Vanzetta; Ivan Teng; Payam A. Saisan; Louise E. Sinks; Anders M. Dale; Sergei A. Vinogradov; David A. Boas

doi:10.1007/978-1-62703-785-3_14

Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Anna Devor, Sava Sakadžić, Mohammad A. Yaseen, Emmanuel Roussakis, Peifang Tian, Hamutal Slovin, Ivo Vanzetta, Ivan Teng, Payam A. Saisan, Louise E. Sinks, Anders M. Dale, Sergei A. Vinogradov, David A. Boas

The Leslie and Susan Gonda Multidisciplinary Brain Research Center

Bar-Ilan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

Original language	English
Title of host publication	Optical Imaging of Neocortical Dynamics
Pages	225-253
Number of pages	29
DOIs	https://doi.org/10.1007/978-1-62703-785-3_14
State	Published - 2014

Publication series

Name	Neuromethods
Volume	85

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CCD
Energy metabolism
Hemoglobin
In vivo imaging
Intrinsic optical signals
Phosphorescence quenching
Two-photon microscopy

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology
General Neuroscience

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10.1007/978-1-62703-785-3_14

Cite this

Devor, A., Sakadžić, S., Yaseen, M. A., Roussakis, E., Tian, P., Slovin, H., Vanzetta, I., Teng, I., Saisan, P. A., Sinks, L. E., Dale, A. M., Vinogradov, S. A., & Boas, D. A. (2014). Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes. In Optical Imaging of Neocortical Dynamics (pp. 225-253). (Neuromethods; Vol. 85). https://doi.org/10.1007/978-1-62703-785-3_14

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abstract = "Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.",

keywords = "CCD, Energy metabolism, Hemoglobin, In vivo imaging, Intrinsic optical signals, Phosphorescence quenching, Two-photon microscopy",

author = "Anna Devor and Sava Sakad{\v z}i{\'c} and Yaseen, {Mohammad A.} and Emmanuel Roussakis and Peifang Tian and Hamutal Slovin and Ivo Vanzetta and Ivan Teng and Saisan, {Payam A.} and Sinks, {Louise E.} and Dale, {Anders M.} and Vinogradov, {Sergei A.} and Boas, {David A.}",

year = "2014",

doi = "10.1007/978-1-62703-785-3_14",

language = "الإنجليزيّة",

isbn = "9781627037846",

series = "Neuromethods",

pages = "225--253",

booktitle = "Optical Imaging of Neocortical Dynamics",

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Devor, A, Sakadžić, S, Yaseen, MA, Roussakis, E, Tian, P, Slovin, H, Vanzetta, I, Teng, I, Saisan, PA, Sinks, LE, Dale, AM, Vinogradov, SA & Boas, DA 2014, Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes. in Optical Imaging of Neocortical Dynamics. Neuromethods, vol. 85, pp. 225-253. https://doi.org/10.1007/978-1-62703-785-3_14

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T1 - Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

AU - Devor, Anna

AU - Sakadžić, Sava

AU - Yaseen, Mohammad A.

AU - Roussakis, Emmanuel

AU - Tian, Peifang

AU - Slovin, Hamutal

AU - Vanzetta, Ivo

AU - Teng, Ivan

AU - Saisan, Payam A.

AU - Sinks, Louise E.

AU - Dale, Anders M.

AU - Vinogradov, Sergei A.

AU - Boas, David A.

PY - 2014

Y1 - 2014

N2 - Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

AB - Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding normal cerebral energy metabolism and its dysregulation in a wide range of clinical conditions. Relevant cerebral pathologies include compromised blood perfusion following stroke and a decrease in efficiency of single-cell respiratory processes that occurs in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this chapter we review a number of quantitative optical approaches to measuring oxygenation of blood and cerebral tissue. These methods can be applied to map the hemodynamic response and study neurovascular and neurometabolic coupling, and can provide microscopic imaging of biomarkers in animal models of human disease, which would be useful for screening potential therapeutic approaches.

KW - CCD

KW - Energy metabolism

KW - Hemoglobin

KW - In vivo imaging

KW - Intrinsic optical signals

KW - Phosphorescence quenching

KW - Two-photon microscopy

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DO - 10.1007/978-1-62703-785-3_14

M3 - فصل

SN - 9781627037846

T3 - Neuromethods

SP - 225

EP - 253

BT - Optical Imaging of Neocortical Dynamics

ER -

Functional imaging of cerebral oxygenation with intrinsic optical contrast and phosphorescent probes

Abstract

Publication series

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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